Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.35 |
| ▸ | FNTB | P49356 | 2/20 | 0.35 |
| ▸ | GLI1 | P08151 | 1/20 | 0.35 |
| ▸ | GLI2 | P10070 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000673 | 0.94 | SOAT1 (0.37) | KMT2AMEN1CYP2D6GLI1GLI2 | |
| SCHEMBL9000579 | 0.94 | KMT2A (0.35) | LMNAKMT2AMEN1FNTAFNTB | |
| SCHEMBL9000608 | 0.94 | FNTA (0.37) | LMNAKMT2AFNTAFNTBNPSR1 | |
| SCHEMBL9000460 | 0.90 | EPHX1 (0.37) | FNTAFNTBSOAT1GRM5EPHX1 | |
| SCHEMBL9000588 | 0.87 | EPHX1 (0.38) | LMNASOAT1GRM5EPHX1L3MBTL1 | |
| SCHEMBL9000753 | 0.87 | SOAT1 (0.39) | LMNAKMT2AMEN1NPSR1SOAT1 | |
| SCHEMBL9000777 | 0.86 | KMT2A (0.37) | LMNAKMT2AMEN1SOAT1 | |
| SCHEMBL9000651 | 0.84 | SOAT1 (0.41) | NPSR1SOAT1EPHX1 | |
| SCHEMBL9000768 | 0.84 | EPHX1 (0.41) | LMNAFNTAFNTBEPHX1L3MBTL1 | |
| SCHEMBL9000831 | 0.84 | TOP2A (0.37) | LMNAKMT2AMEN1NPSR1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |