Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.34 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000550 | 0.84 | SORT1 (0.40) | SOAT1LMNA | |
| SCHEMBL9000743 | 0.82 | SOAT1 (0.38) | SOAT1 | |
| SCHEMBL9000766 | 0.82 | SOAT1 (0.38) | SOAT1CYP3A4HPGD | |
| SCHEMBL9000419 | 0.81 | SOAT1 (0.41) | SOAT1LMNAHDAC8HDAC6DHODH | |
| SCHEMBL9001013 | 0.81 | MAPT (0.42) | SOAT1CYP3A4CYP2C9KDM4EALDH1A1 | |
| SCHEMBL9000614 | 0.80 | SOAT1 (0.38) | SOAT1KDM4EALDH1A1HPGD | |
| SCHEMBL9000682 | 0.78 | SOAT1 (0.40) | SOAT1KDM4EALDH1A1HPGD | |
| SCHEMBL9000644 | 0.77 | PLK1 (0.38) | SOAT1LMNAHPGD | |
| SCHEMBL9000803 | 0.73 | SOAT1 (0.37) | SOAT1 | |
| SCHEMBL9001010 | 0.70 | SOAT1 (0.43) | SOAT1KDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |