Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000550 | 0.89 | SORT1 (0.40) | KMT2ASOAT1 | |
| SCHEMBL9000772 | 0.87 | MAPT (0.43) | MAPTKDM4EPPARGSOAT1 | |
| SCHEMBL9000766 | 0.87 | SOAT1 (0.38) | MEN1KMT2ACYP3A4SOAT1 | |
| SCHEMBL9000743 | 0.87 | SOAT1 (0.38) | MAPTMEN1KMT2ASOAT1 | |
| SCHEMBL9000419 | 0.85 | SOAT1 (0.41) | MEN1KMT2ASOAT1 | |
| SCHEMBL9000644 | 0.81 | PLK1 (0.38) | MEN1KMT2AMAPK1SOAT1 | |
| SCHEMBL9000875 | 0.81 | ABL1 (0.40) | MAPTKDM4EMEN1RECQLKMT2A | |
| SCHEMBL9000573 | 0.79 | MAPT (0.47) | MAPTKDM4EMEN1RECQLKMT2A | |
| SCHEMBL9000802 | 0.78 | MAPT (0.39) | MAPTKDM4EMEN1RECQLKMT2A | |
| SCHEMBL9000864 | 0.74 | ALDH1A1 (0.49) | MAPTMEN1KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |