Terephthalamide

Terephthalamide

SCHEMBL900384

CC1(C(N)(N)C2CCCCC2)CCCCC1.NC(=O)c1ccc(C(N)=O)cc1

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 3/20 0.44
PARP10 Q53GL7 6/20 0.41
PARP15 Q460N3 4/20 0.41
OPRD1 P41143 3/20 0.39
PDE4D Q08499 2/20 0.38
PDE7A Q13946 1/20 0.38
CYP2C9 P11712 1/20 0.38
HPGD P15428 2/20 0.37
RAB9A P51151 2/20 0.37
ALDH1A1 P00352 1/20 0.37
PDE4A P27815 1/20 0.36
PDE4B Q07343 1/20 0.36
PDE4C Q08493 1/20 0.36
PARP2 Q9UGN5 3/20 0.36
OPRK1 P41145 2/20 0.35
NPC1 O15118 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C19 P33261 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
SENP8 Q96LD8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Terephthalamide SCHEMBL2554096 0.85 OPRM1 (0.42) OPRM1PARP10PARP15OPRD1PDE4D
SCHEMBL852183 0.80 ALDH1A1 (0.35) ALDH1A1
Isophthalic Acid SCHEMBL17802593 0.71 KMO (0.43) OPRM1OPRD1PDE4DPDE7ARAB9A
Terephthalamide SCHEMBL5509609 0.70 PARP10 (0.53) PARP10PARP15PDE4DPDE7ACYP2C9
Terephthalamide SCHEMBL12613686 0.69 PARP1 (0.60) PARP10PARP15ALDH1A1PARP2CYP2C19
Terephthalamide SCHEMBL197479 0.69 PARP1 (0.60) PARP10PARP15ALDH1A1PARP2CYP2C19
Terephthalamide SCHEMBL472214 0.69 PARP1 (0.60) PARP10PARP15ALDH1A1PARP2CYP2C19
Terephthalamide SCHEMBL4131585 0.67 PARP1 (0.57) PARP10PARP15ALDH1A1PARP2CYP2C19
SCHEMBL28969909 0.66 PARP1 (0.49) OPRM1PARP10PARP15OPRD1PDE4D
SCHEMBL1160171 0.66 GAA (0.47) OPRM1PARP10PARP15OPRD1PDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2622007-A1 THERMALLY CONDUCTIVE RESIN COMPOSITION E.I. Du Pont De Nemours And Company (US) 2013-08-07 EP disclosed
EP-2456815-A1 THERMALLY CONDUCTIVE POLYMER COMPOSITIONS AND ARTICLES MADE THEREFROM Ticona LLC (US) 2012-05-30 EP disclosed
WO-2012044903-A1 THERMALLY CONDUCTIVE RESIN COMPOSITION E.I. DU PONT DE NEMOURS AND COMPANY (US) 2012-04-05 WO disclosed
WO-2011010291-A1 THERMALLY CONDUCTIVE POLYMER COMPOSITIONS AND ARTICLES MADE THEREFROM TICONA LLC (US) 2011-01-27 WO disclosed