Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | BLM | P54132 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21463 | 0.80 | MAPT (0.41) | ALOX5PTGS2DDAH1MAPTMEN1 | |
| SCHEMBL891446 | 0.80 | ALOX5 (0.56) | ALOX5PTGS2MAPTMEN1KMT2A | |
| Duroquinone SCHEMBL11408085 | 0.72 | DDAH1 (0.36) | ALOX5PTGS2DDAH1MAPTMEN1 | |
| SCHEMBL7115894 | 0.69 | ALOX5 (1.00) | ALOX5PTGS2MAPTMEN1KMT2A | |
| SCHEMBL5160971 | 0.68 | MAPT (0.40) | ALOX5DDAH1MAPTMEN1KMT2A | |
| SCHEMBL28702111 | 0.68 | ALOX5 (0.46) | ALOX5PTGS2BACE1 | |
| SCHEMBL5457397 | 0.68 | MAPT (0.40) | ALOX5DDAH1MAPTMEN1KMT2A | |
| SCHEMBL31415084 | 0.68 | ALOX5 (0.46) | ALOX5PTGS2BACE1 | |
| SCHEMBL28718131 | 0.68 | ALOX5 (0.46) | ALOX5PTGS2MAPTMEN1KMT2A | |
| SCHEMBL2682760 | 0.65 | S100A4 (0.41) | ALOX5DDAH1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2691372-B1 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS | CENTRE NAT RECH SCIENT (FR) | 2019-10-16 | — | — | EP | disclosed |
| US-9409879-B2 | Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2016-08-09 | — | — | US | disclosed |
| US-9409879-B2 | Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2016-08-09 | — | — | US | disclosed |
| WO-2016051799-A1 | 2-AMINOHYDROQUINONE DERIVATIVE AND TAU AGGREGATION INHIBITOR | 学校法人同志社 | 2016-04-07 | — | — | WO | disclosed |
| US-20140121238-A1 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-05-01 | — | — | US | disclosed |
| US-20140121238-A1 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-05-01 | — | — | US | disclosed |
| WO-2012131010-A1 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-10-04 | — | — | WO | disclosed |
| EP-2505583-A1 | Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents | Centre National de la Recherche Scientifique (FR) | 2012-10-03 | — | — | EP | disclosed |
| US-5500760-A | Electrochemichromic solutions, processes for preparing and using the same, and devices manufactured with the same | DONNELLY CORPORATION (US) | 1996-03-19 | — | — | US | disclosed |
| EP-0531143-A2 | Electrochemichromic solutions, processes for preparing and using the same, and devices manufactured with the same | DONNELLY CORPORATION (US) | 1993-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140121238-A1 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS | NQO1, AOX1, CYP4X1 | ALOX5 238/4885PTGS2 320/4885DDAH1 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.