Sugi Predict

Sugi Predict / Compounds / SCHEMBL900568

SCHEMBL900568

SCHEMBL900568

Fc1[c]ccc(OC(F)F)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 1/20 0.35
▸ GFER P55789 1/20 0.35
▸ ADAM17 P78536 1/20 0.35
▸ DRD1 P21728 2/20 0.34
▸ GRM4 Q14833 1/20 0.32
▸ ALDH1A1 P00352 3/20 0.32
▸ ATM Q13315 2/20 0.32
▸ MEN1 O00255 2/20 0.32
▸ LMNA P02545 2/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ HSP90AA1 P07900 1/20 0.32
▸ PKM P14618 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ HTT P42858 1/20 0.32
▸ CCR6 P51684 1/20 0.32
▸ NLRP3 Q96P20 1/20 0.31
▸ MAPT P10636 2/20 0.31
▸ TSHR P16473 1/20 0.31
▸ RAB9A P51151 1/20 0.30
▸ NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4777768 0.82 ALDH1A1 (0.39) ALDH1A1MEN1LMNAKMT2AHPGD
SCHEMBL900731 0.79 ALOX15 (0.35) ALOX15GFERADAM17DRD1ALDH1A1
SCHEMBL1067722 0.79 ALOX15 (0.39) ALOX15GFERADAM17DRD1ALDH1A1
SCHEMBL21680793 0.79 — —
SCHEMBL28741677 0.78 ALOX15 (0.38) ALOX15GFERADAM17DRD1GRM4
SCHEMBL1067134 0.78 ALOX15 (0.34) ALOX15GFERADAM17DRD1ALDH1A1
SCHEMBL401985 0.78 KMT2A (0.36) ALOX15GFERADAM17DRD1GRM4
SCHEMBL1067511 0.78 ALOX15 (0.34) ALOX15GFERADAM17DRD1ALDH1A1
SCHEMBL17164336 0.76 GPBAR1 (0.35) MAPT
SCHEMBL407346 0.75 GPR3 (0.41) ALOX15LMNAPKMMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240009175-A9 TETRAZOLE DERIVATIVES MERCK PATENT GMBH (DE) 2024-01-11 — — US claimed
US-20230271956-A1 AMIDE DERIVATIVES MERCK PATENT GMBH (DE) 2023-08-31 — — US claimed
US-20230149371-A1 TETRAZOLE DERIVATIVES MERCK PATENT GMBH (DE) 2023-05-18 — — US claimed
EP-4121429-A1 CONDENSED PYRIDINE DERIVASTIVES SUBSTITUED BY AMIDE FUNCTIONS AS ACSS2 INHIBITORS Merck Patent GmbH (DE) 2023-01-25 — — EP claimed
EP-4121423-A1 TETRAZOLE DERIVATIVES Merck Patent GmbH (DE) 2023-01-25 — — EP claimed
CN-115443275-A Condensed pyridine derivatives substituted with amide functions as ACSS2 inhibitors 默克专利股份公司 2022-12-06 — — CN claimed
CN-115335371-A Tetrazole derivatives 默克专利股份公司 2022-11-11 — — CN claimed
WO-2021185789-A1 CONDENSED PYRIDINE DERIVASTIVES SUBSTITUED BY AMIDE FUNCTIONS AS ACSS2 INHIBITORS MERCK PATENT GMBH (DE) 2021-09-23 — — WO claimed
WO-2021185793-A1 TETRAZOLE DERIVATIVES MERCK PATENT GMBH (DE) 2021-09-23 — — WO claimed
US-20080312271-A1 AZABENZIMIDAZOLYL COMPOUNDS PFIZER INC. 2008-12-18 — — US claimed
US-20080280933-A1 BENZIMIDAZOLYL COMPOUNDS EFREMOV IVAN 2008-11-13 — — US claimed
WO-2008012623-A1 BENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR PFIZER PRODUCTS INC. (US) 2008-01-31 — — WO claimed
WO-2008012622-A2 AZABENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR PFIZER PRODUCTS INC. (US) 2008-01-31 — — WO claimed
WO-2008010061-A2 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION GLENMARK PHARMACEUTICALS S.A. (US) 2008-01-24 — — WO claimed
US-20240009175-A9 TETRAZOLE DERIVATIVES MERCK PATENT GMBH (DE) 2024-01-11 — — US disclosed
US-20230271956-A1 AMIDE DERIVATIVES MERCK PATENT GMBH (DE) 2023-08-31 — — US disclosed
US-20230149371-A1 TETRAZOLE DERIVATIVES MERCK PATENT GMBH (DE) 2023-05-18 — — US disclosed
WO-2008010061-A2 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION GLENMARK PHARMACEUTICALS S.A. (US) 2008-01-24 — — WO disclosed
EP-0865432-A1 PHENYLACETIC ACID DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES AND/OR FUNGICIDES BASF AKTIENGESELLSCHAFT (DE) 1998-09-23 — — EP disclosed
WO-1997020816-A1 PHENYLACETIC ACID DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES AND/OR FUNGICIDES BASF AKTIENGESELLSCHAFT (DE) 1997-06-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240009175-A9 TETRAZOLE DERIVATIVES VHL, BRCA1, POT1 ALOX15 2620/4885GFER 3450/4885ADAM17 4022/4885
US-20080280933-A1 BENZIMIDAZOLYL COMPOUNDS PAICS, TMBIM6, ABCG2 ALOX15 3976/4885GFER 4624/4885ADAM17 3397/4885
US-20080312271-A1 AZABENZIMIDAZOLYL COMPOUNDS AZI2, PAICS, UGT2B7 ALOX15 3537/4885GFER 4456/4885ADAM17 3834/4885
US-20230271956-A1 AMIDE DERIVATIVES BRCA1, HRAS, PCNA ALOX15 2890/4885GFER 3406/4885ADAM17 4673/4885
US-20230149371-A1 TETRAZOLE DERIVATIVES VHL, BRCA1, POT1 ALOX15 2620/4885GFER 3450/4885ADAM17 4022/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.