SCHEMBL1067722

SCHEMBL1067722

FC(F)Oc1cc[c]c(Br)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.39
GFER P55789 1/20 0.39
ADAM17 P78536 1/20 0.39
DRD1 P21728 2/20 0.34
TAS2R14 Q9NYV8 1/20 0.33
MEP1B Q16820 1/20 0.33
MAPT P10636 4/20 0.32
ALDH1A1 P00352 4/20 0.32
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
TEAD4 Q15561 1/20 0.32
ATM Q13315 2/20 0.32
LMNA P02545 2/20 0.32
HSP90AA1 P07900 1/20 0.32
PKM P14618 1/20 0.32
HPGD P15428 1/20 0.32
HTT P42858 1/20 0.32
CCR6 P51684 1/20 0.32
KDM4E B2RXH2 1/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28542391 0.82 ALDH1A1 (0.39) ALDH1A1MEN1KMT2ALMNAHPGD
SCHEMBL900568 0.79 ALOX15 (0.35) ALOX15GFERADAM17DRD1TAS2R14
SCHEMBL900731 0.79 ALOX15 (0.35) ALOX15GFERADAM17DRD1TAS2R14
SCHEMBL457747 0.78 GPR3 (0.40) ALOX15MAPTALDH1A1LMNAPKM
SCHEMBL1067134 0.78 ALOX15 (0.34) ALOX15GFERADAM17DRD1MAPT
SCHEMBL28741677 0.78 ALOX15 (0.38) ALOX15GFERADAM17DRD1TAS2R14
SCHEMBL401985 0.78 KMT2A (0.36) ALOX15GFERADAM17DRD1MAPT
SCHEMBL1067511 0.78 ALOX15 (0.34) ALOX15GFERADAM17DRD1MAPT
SCHEMBL1067459 0.75 MEN1 (0.35) ALOX15GFERADAM17DRD1MAPT
SCHEMBL1068538 0.75 POLB (0.36) ALOX15GFERADAM17DRD1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240108006-A1 PESTICIDALLY ACTIVE HETEROAROMATIC COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2024-04-04 US disclosed
WO-2024022910-A1 1-[1-[2-(PYRIMIDIN-4-YL)-1,2,4-TRIAZOL-3-YL]ETHYL]-3-[2,4-DICHLORO-5-PHENYL]UREA DERIVATIVES AND SIMILAR COMPOUNDS AS PESTICIDES SYNGENTA CROP PROTECTION AG (CH) 2024-02-01 WO disclosed
CN-117412961-A Pesticidally active heteroaromatic compounds 先正达农作物保护股份公司 2024-01-16 CN disclosed
EP-4281185-A2 PESTICIDALLY ACTIVE HETEROAROMATIC COMPOUNDS Syngenta Crop Protection AG (CH) 2023-11-29 EP disclosed
US-20230139936-A1 SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION BAYER AKTIENGESELLSCHAFT (DE) 2023-05-04 US disclosed
WO-2011006886-A2 AZOLE COMPOUNDS CARRYING A SULFUR SUBSTITUENT XIV BASF SE (DE) 2011-01-20 WO disclosed
WO-2010149758-A1 ANTIFUNGAL 1, 2, 4-TRIAZOLYL DERIVATIVES BASF SE (DE) 2010-12-29 WO disclosed
EP-1358169-A2 DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE F. HOFFMANN-LA ROCHE AG (CH) 2003-11-05 EP disclosed
WO-2002057261-A2 DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE F. HOFFMANN-LA ROCHE AG (CH) 2002-07-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230139936-A1 SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION DGKZ, DGKA, DGKG ALOX15 1381/4885GFER 2873/4885ADAM17 3158/4885
US-20240108006-A1 PESTICIDALLY ACTIVE HETEROAROMATIC COMPOUNDS DDT, ACHE, GSTO1 ALOX15 762/4885GFER 876/4885ADAM17 1734/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.