Sugi Predict

Sugi Predict / Compounds / SCHEMBL401985

SCHEMBL401985

SCHEMBL401985

FC(F)Oc1cc[c]c(Cl)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 5/20 0.36
▸ MAPT P10636 5/20 0.36
▸ MEN1 O00255 4/20 0.36
▸ LMNA P02545 4/20 0.36
▸ NPSR1 Q6W5P4 3/20 0.36
▸ RAB9A P51151 3/20 0.36
▸ SENP8 Q96LD8 1/20 0.36
▸ SENP7 Q9BQF6 1/20 0.36
▸ SENP6 Q9GZR1 1/20 0.36
▸ HTT P42858 2/20 0.34
▸ ATM Q13315 2/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ HSP90AA1 P07900 1/20 0.34
▸ PKM P14618 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ CCR6 P51684 1/20 0.34
▸ ALOX15 P16050 1/20 0.34
▸ GFER P55789 1/20 0.34
▸ ADAM17 P78536 1/20 0.34
▸ DRD1 P21728 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4231182 0.80 ALDH1A1 (0.39) KMT2ALMNAALDH1A1HPGDGAA
SCHEMBL1067722 0.78 ALOX15 (0.39) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL900731 0.78 ALOX15 (0.35) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL900568 0.78 ALOX15 (0.35) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL1067134 0.76 ALOX15 (0.34) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL28741677 0.76 ALOX15 (0.38) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL1067511 0.76 ALOX15 (0.34) KMT2AMAPTMEN1LMNAHTT
SCHEMBL407097 0.76 GPR3 (0.40) MAPTLMNARAB9APKMALOX15
SCHEMBL5808352 0.74 MEN1 (0.33) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL1067459 0.73 MEN1 (0.35) KMT2AMAPTMEN1LMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2389066-B1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LTD (GB) 2017-07-05 — — EP claimed
US-20140378305-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2014-12-25 — — US claimed
US-8895474-B2 Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds SYNGENTA LIMITED (GB) 2014-11-25 — — US claimed
US-20080312271-A1 AZABENZIMIDAZOLYL COMPOUNDS PFIZER INC. 2008-12-18 — — US claimed
US-20080280933-A1 BENZIMIDAZOLYL COMPOUNDS EFREMOV IVAN 2008-11-13 — — US claimed
WO-2008012623-A1 BENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR PFIZER PRODUCTS INC. (US) 2008-01-31 — — WO claimed
WO-2008012622-A2 AZABENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR PFIZER PRODUCTS INC. (US) 2008-01-31 — — WO claimed
US-20240217969-A1 SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2024-07-04 — — US disclosed
EP-4313971-A1 SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS Nerviano Medical Sciences S.r.l. (IT) 2024-02-07 — — EP disclosed
CN-117157289-A Substituted pyrrolecarboxamides, process for their preparation and their use as kinase inhibitors 内尔维亚诺医疗科学公司 2023-12-01 — — CN disclosed
EP-2389066-B1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LTD (GB) 2017-07-05 — — EP disclosed
EP-2387569-B1 HERBCIDES SYNGENTA LTD (GB) 2016-06-15 — — EP disclosed
US-9167817-B2 Process using Grignard reagents BASF SE (DE) 2015-10-27 — — US disclosed
WO-2008012623-A1 BENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR PFIZER PRODUCTS INC. (US) 2008-01-31 — — WO disclosed
WO-2008012622-A2 AZABENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR PFIZER PRODUCTS INC. (US) 2008-01-31 — — WO disclosed
US-20070043056-A1 5-Substituted-2-arylpyrazines NEUROGEN CORPORATION (US) 2007-02-22 — — US disclosed
US-7179807-B2 5-substituted-2-arylpyrazines NEUROGEN CORPORATION (US) 2007-02-20 — — US disclosed
EP-1554258-A1 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS NEUROGEN CORPORATION (US) 2005-07-20 — — EP disclosed
US-20040106620-A1 5-Substituted-2-arylpyrazines NEUROGEN CORPORATION 2004-06-03 — — US disclosed
WO-2004018437-A1 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS NEUROGEN CORPORATION (US) 2004-03-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080280933-A1 BENZIMIDAZOLYL COMPOUNDS PAICS, TMBIM6, ABCG2 KMT2A 3751/4885MAPT 2472/4885MEN1 847/4885
US-20040106620-A1 5-Substituted-2-arylpyrazines HTR5A, CRHR2, HTR2C KMT2A 3153/4885MAPT 2932/4885MEN1 3330/4885
US-20080312271-A1 AZABENZIMIDAZOLYL COMPOUNDS AZI2, PAICS, UGT2B7 KMT2A 2252/4885MAPT 3948/4885MEN1 812/4885
US-20240217969-A1 SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS CDC7, CDK7, CDK17 KMT2A 1804/4885MAPT 2344/4885MEN1 2354/4885
US-20140378305-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 KMT2A 839/4885MAPT 3785/4885MEN1 4216/4885
US-20070043056-A1 5-Substituted-2-arylpyrazines HTR5A, CRHR2, HTR2C KMT2A 3153/4885MAPT 2932/4885MEN1 3330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.