SCHEMBL9169744

SCHEMBL9169744

COc1ccc(OC(F)=C(F)F)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.52
CA2 P00918 4/20 0.52
CA7 P43166 2/20 0.52
CA9 Q16790 2/20 0.52
CA12 O43570 1/20 0.52
CA14 Q9ULX7 1/20 0.52
ACHE P22303 1/20 0.44
LTA4H P09960 1/20 0.43
ESR2 Q92731 1/20 0.43
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43
ENPP2 Q13822 1/20 0.43
TDP1 Q9NUW8 3/20 0.42
MAPK1 P28482 2/20 0.42
GAA P10253 2/20 0.41
MAPT P10636 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
LMNA P02545 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9006669 0.88 NFE2L2 (0.58) SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19
SCHEMBL9006667 0.88 NFE2L2 (0.58) SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19
SCHEMBL4530562 0.87 RAB9A (0.35) ESR2TDP1MAPTSMN1; SMN2LMNA
SCHEMBL12834526 0.87 HSD11B1 (0.43) CA1CA2CA7CA9CA12
SCHEMBL13455409 0.81 LMNA (0.55) CA1CA2CES2CES1GAA
SCHEMBL9909122 0.81 LMNA (0.52) ACHETDP1GAAMAPTLMNA
SCHEMBL1505815 0.80 KIF11 (0.39) ESR2MAPK1GAASMN1; SMN2LMNA
SCHEMBL12833375 0.80 KIF11 (0.39) ESR2MAPK1GAASMN1; SMN2LMNA
SCHEMBL12833374 0.80 KMT2A (0.43) CA1CA2LTA4HESR2TDP1
SCHEMBL8934991 0.80 KIF11 (0.39) ESR2MAPK1GAASMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3613810-A1 ARTICLES AND COMPOSITIONS COMPRISING HOST POLYMERS AND CHROMOPHORES AND METHODS OF PRODUCING THE SAME General Dynamics Mission Systems, Inc. (US) 2020-02-26 EP disclosed
US-20200048428-A1 ARTICLES AND COMPOSITIONS COMPRISING HOST POLYMERS AND CHROMOPHORES AND METHODS OF PRODUCING THE SAME GENERAL DYNAMICS MISSION SYSTEMS, INC. 2020-02-13 US disclosed
US-9370750-B2 Polyolefin-PFCB ionomer GM Global Technology Operations LLC (US) 2016-06-21 US disclosed
US-20140065514-A1 Polyolefin-PFCB Ionomer GM Global Technology Operations LLC (US) 2014-03-06 US disclosed
US-20110245429-A1 Cross Linked Organic Conductive Layer GOUGH, NEIL (GB) 2011-10-06 US disclosed
EP-0428709-B1 REACTIVE COMPOUNDS CONTAINING PERFLUOROVINYL GROUPS DOW CHEMICAL CO (US) 1995-05-24 EP disclosed
US-5210265-A Multistage reaction to form monomers for polymers such as polyesters by dimerization of trifluorovinyl compounds by dehalogenation and cyclization THE DOW CHEMICAL COMPANY (US) 1993-05-11 US disclosed
US-5198513-A Compounds for engineering thermoplastics or dimers THE DOW CHEMICAL COMPANY (US) 1993-03-30 US disclosed
US-5037919-A Endcapper for polyesters, polycarbonates, polyamides and polyethers THE DOW CHEMICAL COMPANY (US) 1991-08-06 US disclosed
EP-0429618-A1 REACTIVE COMPOUNDS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1991-06-05 EP disclosed
US-5021602-A Monomers for condensation polymers THE DOW CHEMICAL COMPANY (US) 1991-06-04 US disclosed
EP-0428709-A1 REACTIVE COMPOUNDS CONTAINING PERFLUOROVINYL GROUPS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
WO-1990015044-A2 REACTIVE COMPOUNDS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed
WO-1990015042-A2 REACTIVE COMPOUNDS CONTAINING PERFLUOROVINYL GROUPS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110245429-A1 Cross Linked Organic Conductive Layer GJB2, GJA1, KCNH3 CA1 2557/4885CA2 2055/4885CA7 1930/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.