Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.47 |
| ▸ | SLC6A2 known ✓ | P23975 | 11/20 | 0.44 |
| ▸ | SLC6A4 known ✓ | P31645 | 9/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 6/20 | 0.42 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9013959 | 1.00 | HRH1 (0.47) | HRH1SLC6A2SLC6A4SLC6A3KCNH2 | |
| Fumaric Acid SCHEMBL9014052 | 0.87 | HRH1 (0.48) | HRH1SLC6A2SLC6A4KCNH2 | |
| Fumaric Acid SCHEMBL9014048 | 0.87 | HRH1 (0.48) | HRH1SLC6A2SLC6A4KCNH2 | |
| Fumaric Acid SCHEMBL9013837 | 0.85 | HRH1 (0.48) | HRH1SLC6A2SLC6A4KCNH2CTSL | |
| Fumaric Acid SCHEMBL9013846 | 0.85 | HRH1 (0.48) | HRH1SLC6A2SLC6A4KCNH2CTSL | |
| SCHEMBL9013965 | 0.79 | LMNA (0.43) | CTSLCTSSCTSK | |
| SCHEMBL9013842 | 0.76 | KCNH2 (0.40) | HRH1KCNH2CTSLCTSSCTSK | |
| SCHEMBL8800057 | 0.75 | HRH1 (0.47) | HRH1KCNH2 | |
| Fumaric Acid SCHEMBL9013889 | 0.75 | RAB9A (0.50) | HRH1KCNH2 | |
| SCHEMBL9022785 | 0.74 | HRH1 (0.46) | HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580883-A | INHIBITING DEGENERATION AND NECROCYTOSIS OF CEREBRAL NERVE CELLS CAUSED BY OXIDATIVE STRESS INDUCING GLUTAMIC ACID IN MAMMALS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-03 | — | — | US | disclosed |
| EP-0449195-B1 | Aminobenzene compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0449195-A2 | Aminobenzene compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |