Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10407545 | 0.82 | HSP90AA1 (0.38) | ALDH1A1CHRNB4CHRNA3HSP90AA1MEN1 | |
| SCHEMBL9014699 | 0.78 | PNMT (0.40) | CHRNB4CHRNA3HSP90AA1NOS3NOS1 | |
| SCHEMBL9014349 | 0.75 | CHRNB4 (0.36) | ALDH1A1CHRNB4CHRNA3ACHEMEN1 | |
| SCHEMBL9014407 | 0.74 | DRD2 (0.37) | CHRNB4CHRNA3NOS3NOS1NOS2 | |
| SCHEMBL9014727 | 0.74 | KCNH2 (0.38) | SMN1; SMN2LMNACRHBPCRHR2 | |
| SCHEMBL9014394 | 0.72 | KCNH2 (0.64) | ALDH1A1GAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10845095 | 0.70 | MEN1 (0.54) | TERTALDH1A1CHRNB4CHRNA3MEN1 | |
| SCHEMBL9014335 | 0.69 | KDM4E (0.37) | ALDH1A1GAACHRNB4CHRNA3KDM4E | |
| SCHEMBL6350114 | 0.69 | HSP90AA1 (0.47) | ALDH1A1CHRNB4CHRNA3HSP90AA1MEN1 | |
| SCHEMBL6347584 | 0.69 | HSP90AA1 (0.43) | ALDH1A1CHRNB4CHRNA3HSP90AA1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |