Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9234439 | 0.83 | DRD3 (0.37) | KDM4EGAAMAPTHTR1AHTR1D | |
| SCHEMBL9014788 | 0.83 | ADRA2A (0.40) | HTR1AHTR1DHTR2CMTNR1AMTNR1B | |
| SCHEMBL9014302 | 0.80 | HTR1A (0.47) | HTR1AMTNR1AMTNR1B | |
| SCHEMBL9014733 | 0.80 | DRD2 (0.39) | ALDH1A1 | |
| SCHEMBL9014727 | 0.79 | KCNH2 (0.38) | MTNR1AMTNR1B | |
| SCHEMBL10408558 | 0.74 | MAP3K14 (0.45) | HTR1AMTNR1AMTNR1B | |
| SCHEMBL10407574 | 0.74 | ADRA2A (0.36) | HTR1AMTNR1AMTNR1B | |
| SCHEMBL10407837 | 0.74 | DRD3 (0.39) | KDM4EHTR1AHTR1DHTR2CMTNR1A | |
| SCHEMBL8139731 | 0.73 | MTNR1A (0.36) | KDM4EGAAMAPTHTR1AHTR1D | |
| SCHEMBL9014396 | 0.71 | MAP3K14 (0.35) | MTNR1AMTNR1BCHRNB4CHRNA3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |