Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 3/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 7/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014643 | 0.78 | TERT (0.38) | HSP90AA1SMN1; SMN2CHRNB4CHRNA3NOS3 | |
| SCHEMBL8667329 | 0.75 | GRIN2B (0.43) | PNMTHTR6HSP90AA1GRIN2B | |
| SCHEMBL8702101 | 0.72 | GRIN2B (0.42) | PNMTHSP90AA1GRIN2BCHRNB2CHRNB4 | |
| SCHEMBL8548146 | 0.72 | PNMT (0.44) | PNMTHSP90AA1GRIN2BCHRNA7SMN1; SMN2 | |
| SCHEMBL10407545 | 0.72 | HSP90AA1 (0.38) | HSP90AA1SMN1; SMN2CHRNB4CHRNA3MEN1 | |
| SCHEMBL10551218 | 0.71 | CYP19A1 (0.54) | — | |
| SCHEMBL6668520 | 0.71 | FFAR1 (0.55) | GRIN2B | |
| SCHEMBL9014412 | 0.70 | KCNH2 (0.52) | — | |
| SCHEMBL7509358 | 0.70 | HSP90AA1 (0.47) | PNMTHSP90AA1GRIN2BCHRNB2CHRNB4 | |
| SCHEMBL2244560 | 0.69 | LAP3 (0.48) | PNMTHSP90AA1GRIN2BCHRNA7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |