Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014357 | 0.92 | DRD2 (0.54) | DRD2SIGMAR1PRCP | |
| SCHEMBL9014672 | 0.90 | DRD2 (0.55) | DRD2SIGMAR1SLC18A3OPRM1 | |
| SCHEMBL9014782 | 0.85 | KCNH2 (0.47) | DRD2 | |
| SCHEMBL9014708 | 0.85 | KCNH2 (0.61) | DRD2 | |
| SCHEMBL11839176 | 0.83 | DRD2 (0.57) | DRD2SIGMAR1SLC18A3OPRM1OPRL1 | |
| SCHEMBL9014839 | 0.79 | DRD2 (0.54) | DRD2SIGMAR1SLC18A3OPRM1 | |
| SCHEMBL9014719 | 0.77 | SIGMAR1 (0.52) | DRD2SIGMAR1SLC18A3CARM1PRMT6 | |
| SCHEMBL6790341 | 0.76 | DRD2 (0.55) | DRD2SIGMAR1SLC18A3OPRM1OPRL1 | |
| SCHEMBL11867523 | 0.76 | DRD2 (0.53) | DRD2SIGMAR1SLC18A3CARM1PRMT6 | |
| SCHEMBL9014652 | 0.74 | KCNH2 (0.48) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |