Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12266239 | 0.90 | CYP11B2 (0.46) | ADAMTS5CYP11B2IDO1TDO2MEN1 | |
| SCHEMBL902176 | 0.84 | GPR119 (0.47) | ALDH1A1MEN1KMT2AUSP30LMNA | |
| SCHEMBL3803696 | 0.83 | NOS3 (0.38) | CYP11B2CHEK1FFAR1MEN1KMT2A | |
| SCHEMBL2068140 | 0.83 | CHRNB2 (0.38) | CHRNB2CHRNA4FFAR1 | |
| SCHEMBL1981629 | 0.83 | CHRNB2 (0.38) | CHRNB2CHRNA4FFAR1 | |
| SCHEMBL14159644 | 0.81 | CHRM4 (0.33) | PDGFRBKDRFFAR1USP30 | |
| SCHEMBL901893 | 0.81 | USP2 (0.42) | ALDH1A1ROCK1MEN1KMT2ALMNA | |
| SCHEMBL578443 | 0.80 | LIPG (0.44) | ALDH1A1MEN1KMT2ATSHRHTT | |
| SCHEMBL1982780 | 0.80 | CCR6 (0.39) | CYP11B2ALDH1A1CHRNB2CHRNA4FFAR1 | |
| SCHEMBL3758304 | 0.80 | ADAMTS5 (0.42) | ADAMTS5ROCK1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |