Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902454 | 0.86 | ASIC3 (0.42) | MEN1KMT2AHTTL3MBTL1LMNA | |
| SCHEMBL1704199 | 0.79 | TAAR1 (0.55) | MEN1KMT2AHTTL3MBTL1ALDH1A1 | |
| SCHEMBL1788632 | 0.77 | DHODH (0.43) | MEN1KMT2AHTTL3MBTL1LMNA | |
| SCHEMBL902758 | 0.77 | KARS1 (0.64) | MEN1KMT2AHTTALDH1A1LMNA | |
| SCHEMBL1705304 | 0.77 | KARS1 (0.47) | CNR2 | |
| SCHEMBL1704492 | 0.76 | KARS1 (0.51) | — | |
| SCHEMBL901864 | 0.75 | KARS1 (0.49) | — | |
| SCHEMBL4158364 | 0.74 | OPRK1 (0.55) | MEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL1026339 | 0.74 | TAAR1 (0.47) | MEN1KMT2AHTTL3MBTL1ALDH1A1 | |
| SCHEMBL901976 | 0.74 | ALDH1A1 (0.46) | DAGLAALDH1A1LMNAHPGDCFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |