Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018004 | 0.91 | P4HTM (0.48) | EGFRP4HTMPTGS2GABRA5OPRM1 | |
| SCHEMBL9018050 | 0.90 | P4HTM (0.44) | EGFRP4HTMGABRA5MEN1USP2 | |
| SCHEMBL9018337 | 0.90 | ALDH1A1 (0.45) | EGFRP4HTMKMT2ASMN1; SMN2 | |
| SCHEMBL9017994 | 0.89 | EGFR (0.41) | EGFRP4HTMPTGS2KMT2AEPHX2 | |
| SCHEMBL9018016 | 0.88 | SCN3A (0.49) | P4HTMOPRM1OPRD1OPRK1CA12 | |
| SCHEMBL9018412 | 0.88 | OPRM1 (0.48) | EGFRP4HTMGABRA5OPRM1OPRD1 | |
| SCHEMBL9018169 | 0.88 | CA2 (0.50) | EGFRP4HTM | |
| SCHEMBL9018013 | 0.88 | P4HTM (0.58) | EGFRP4HTMPTGS2GABRA5 | |
| SCHEMBL9018479 | 0.88 | EGFR (0.43) | EGFRP4HTMPTGS2GABRA5OPRM1 | |
| SCHEMBL9018266 | 0.87 | HPGD (0.47) | EGFRP4HTMMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |