Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018343 | 0.93 | CA1 (0.43) | P4HTMKDM4ELMNAHDAC2HDAC8 | |
| SCHEMBL9018356 | 0.93 | ALDH1A1 (0.41) | P4HTMOPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL9018198 | 0.92 | OPRM1 (0.40) | P4HTMKDM4ELMNAHDAC2HDAC8 | |
| SCHEMBL9018274 | 0.91 | RAB9A (0.48) | P4HTMKDM4ELMNAHDAC2HDAC8 | |
| SCHEMBL9018096 | 0.91 | PTPN1 (0.47) | P4HTMLMNASMN1; SMN2OPRM1OPRD1 | |
| SCHEMBL9018311 | 0.90 | P4HTM (0.42) | P4HTMKDM4ELMNAHDAC2HDAC8 | |
| SCHEMBL7869478 | 0.90 | KDM4E (0.44) | P4HTMKDM4ELMNAHDAC2HDAC8 | |
| SCHEMBL9018282 | 0.89 | RAB9A (0.53) | P4HTMHDAC2HDAC8HDAC6RAB9A | |
| SCHEMBL7870343 | 0.88 | RAB9A (0.42) | P4HTMKDM4ELMNAHDAC2HDAC8 | |
| SCHEMBL9018117 | 0.88 | OPRM1 (0.40) | P4HTMKDM4ELMNAHDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |