Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | IDE | P14735 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MYOF | Q9NZM1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018378 | 0.98 | RAB9A (0.43) | ALDH1A1CYP2D6CYP2C9HPGDCYP2C19 | |
| SCHEMBL9018066 | 0.94 | RAB9A (0.48) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9018465 | 0.92 | ALDH1A1 (0.44) | ALDH1A1CYP2D6CYP2C9HPGDCYP2C19 | |
| SCHEMBL9018499 | 0.92 | OPRK1 (0.44) | ALDH1A1CYP2D6CYP2C9HPGDCYP2C19 | |
| SCHEMBL9018007 | 0.92 | ALDH1A1 (0.46) | ALDH1A1CYP2D6CYP2C9HPGDCYP2C19 | |
| SCHEMBL9018053 | 0.91 | CA2 (0.40) | SMN1; SMN2HDAC6L3MBTL1P4HTM | |
| SCHEMBL9018075 | 0.91 | SMN1; SMN2 (0.43) | MAPTSMN1; SMN2RAB9AP4HTMHTT | |
| SCHEMBL9018406 | 0.91 | RAB9A (0.45) | ALDH1A1KDM4EMAPTSMN1; SMN2RAB9A | |
| SCHEMBL9018122 | 0.90 | HTT (0.50) | ALDH1A1RAB9AHDAC2HDAC8HDAC6 | |
| SCHEMBL9018286 | 0.90 | GABRA5 (0.40) | ALDH1A1HPGDKDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |