Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 5/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902759 | 0.83 | ADORA2A (0.60) | LMNAMAPTADORA2A | |
| SCHEMBL22801081 | 0.82 | FBP1 (0.48) | DHFRHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL901638 | 0.81 | PRKD3 (0.43) | ASIC3NOS3NOS1MAPK1LMNA | |
| SCHEMBL5238969 | 0.79 | USP2 (0.59) | HTR1AHTR7USP2MAPK1LMNA | |
| SCHEMBL901682 | 0.78 | ASIC3 (0.44) | ASIC3DHFRNOS3NOS1SCD | |
| SCHEMBL3119833 | 0.77 | ADRA2C (0.59) | HTR1AHTR2AHTR7HTR6USP2 | |
| SCHEMBL27913890 | 0.75 | GRIN2D (0.48) | MAPK1MEN1KMT2ASLC6A7SMN1; SMN2 | |
| SCHEMBL901876 | 0.75 | KARS1 (0.71) | DHFRUSP2MAPK1TSHRMEN1 | |
| SCHEMBL901679 | 0.74 | MAPT (0.46) | ASIC3NOS3NOS1LMNAMAPT | |
| SCHEMBL1704829 | 0.73 | KARS1 (0.43) | DHFRUSP2MAPK1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |