Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704583 | 0.89 | ADORA2A (0.48) | KARS1LMNAALDH1A1JAK2JAK3 | |
| SCHEMBL902923 | 0.83 | NPC1 (0.36) | KARS1LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL902774 | 0.81 | ALDH1A1 (0.37) | KARS1LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL901876 | 0.78 | KARS1 (0.71) | KARS1ALDH1A1TP53BP1DHFRUSP2 | |
| SCHEMBL901891 | 0.77 | KARS1 (0.73) | KARS1LMNARAB9A | |
| SCHEMBL902891 | 0.75 | KARS1 (0.45) | KARS1LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL1705277 | 0.73 | JAK2 (0.44) | ALDH1A1JAK2JAK3HPGD | |
| SCHEMBL901843 | 0.73 | ASIC3 (0.46) | LMNAADORA2AMAPTDHFRUSP2 | |
| SCHEMBL902983 | 0.71 | KARS1 (0.64) | KARS1JAK2JAK3ADORA2ADHFR | |
| SCHEMBL1704662 | 0.69 | KARS1 (0.72) | KARS1LMNAALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |