Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 3/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9020656 | 0.94 | GPR119 (0.43) | JAK2JAK1GPR119RECQLHPGD | |
| SCHEMBL9399808 | 0.87 | RIPK1 (0.35) | JAK2JAK1GPR119NR1H2SPR | |
| SCHEMBL9399696 | 0.86 | RIPK1 (0.34) | JAK2JAK1GPR119NR1H2SPR | |
| SCHEMBL9399942 | 0.85 | CCR5 (0.35) | JAK2JAK1GPR119NR1H2SPR | |
| SCHEMBL9400105 | 0.83 | NR1H2 (0.35) | NR1H2RECQLSPR | |
| SCHEMBL31040353 | 0.83 | NR1H2 (0.35) | NR1H2SPR | |
| SCHEMBL8112414 | 0.83 | CHRM2 (0.34) | JAK2JAK1GPR119SPR | |
| SCHEMBL9399969 | 0.83 | CHRM2 (0.34) | JAK2JAK1GPR119SPR | |
| SCHEMBL9399192 | 0.82 | NR1H2 (0.34) | NR1H2SPR | |
| SCHEMBL9020556 | 0.81 | CCR5 (0.43) | JAK2JAK1GPR119HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449191-B1 | 2-(Substituted pyrrolidinylthio)carbapenem derivatives | BANYU PHARMA CO LTD (JP) | 1996-07-03 | — | — | EP | disclosed |
| US-5438054-A | Antibacterial agent | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1995-08-01 | — | — | US | disclosed |
| US-5374720-A | A thienamycins bactericides has nontoxic, side effect reduction against the kidney and central nervous system | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-12-20 | — | — | US | disclosed |
| WO-1991014687-A1 | 2-(SUBSTITUTED PYRROLIDINYLTHIO)CARBAPENEM DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-10-03 | — | — | WO | disclosed |
| EP-0449191-A1 | 2-(Substituted pyrrolidinylthio)carbapenem derivatives | Banyu Pharmaceutical Co., Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |