Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | SPR | P35270 | 2/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9399808 | 0.99 | RIPK1 (0.35) | RIPK1CHRM2CHRM1CHRM3PREP | |
| SCHEMBL9020656 | 0.90 | GPR119 (0.43) | GPR119JAK2JAK1 | |
| SCHEMBL9400105 | 0.88 | NR1H2 (0.35) | CHRM2CHRM1CHRM3PREPSPR | |
| SCHEMBL9020185 | 0.86 | JAK2 (0.42) | GPR119SPRNR1H2JAK2JAK1 | |
| SCHEMBL31040353 | 0.85 | NR1H2 (0.35) | CHRM2CHRM1CHRM3PREPSPR | |
| SCHEMBL9399969 | 0.85 | CHRM2 (0.34) | CHRM2CHRM1CHRM3GPR119SPR | |
| SCHEMBL9399942 | 0.85 | CCR5 (0.35) | CHRM2CHRM1CHRM3PREPGPR119 | |
| SCHEMBL8112414 | 0.85 | CHRM2 (0.34) | CHRM2CHRM1CHRM3GPR119SPR | |
| SCHEMBL8902543 | 0.84 | CHRM2 (0.34) | CHRM2CHRM1CHRM3PREPALDH1A1 | |
| SCHEMBL9399192 | 0.82 | NR1H2 (0.34) | CHRM2CHRM1CHRM3SPRNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374720-A | A thienamycins bactericides has nontoxic, side effect reduction against the kidney and central nervous system | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-12-20 | — | — | US | disclosed |