Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 13/20 | 0.61 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | METAP2 | P50579 | 2/20 | 0.50 |
| ▸ | METAP1 | P53582 | 2/20 | 0.50 |
| ▸ | CBFB | Q13951 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10189200 | 0.80 | DGAT1 (0.71) | DGAT1SOAT1KCNH2 | |
| SCHEMBL900860 | 0.80 | DGAT1 (0.63) | DGAT1SOAT1KCNH2 | |
| SCHEMBL10189573 | 0.79 | DGAT1 (0.55) | DGAT1SOAT1NPC1RIPK1 | |
| SCHEMBL10189566 | 0.76 | DGAT1 (0.77) | DGAT1SOAT1KCNH2 | |
| SCHEMBL902557 | 0.76 | DGAT1 (0.86) | DGAT1SOAT1KCNH2 | |
| SCHEMBL4181947 | 0.75 | NPC1 (0.59) | DGAT1SOAT1KCNH2NPC1METAP2 | |
| SCHEMBL4183736 | 0.74 | CBFB (0.81) | NPC1METAP2METAP1CBFBADORA3 | |
| SCHEMBL4182090 | 0.73 | METAP2 (0.62) | DGAT1SOAT1KCNH2NPC1METAP2 | |
| SCHEMBL10189208 | 0.72 | S1PR1 (0.42) | DGAT1NPC1CBFB | |
| SCHEMBL902210 | 0.71 | PKN1 (0.60) | DGAT1SOAT1KCNH2METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |