Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791781 | 0.80 | ITGB3 (0.57) | MAPTADRB2NCF1PLD1ITGB3 | |
| SCHEMBL9023933 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2TRPV1MAPTGFERCYP46A1 | |
| SCHEMBL9024669 | 0.78 | ITGB3 (0.60) | SMN1; SMN2TRPV1MAPTGFERCYP46A1 | |
| Hydrochloric Acid SCHEMBL9023772 | 0.77 | ITGB3 (0.59) | SMN1; SMN2TRPV1MAPTGFERCYP46A1 | |
| SCHEMBL9023588 | 0.77 | DPP7 (0.67) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9024246 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2TRPV1MAPTGFERCYP46A1 | |
| Hydrochloric Acid SCHEMBL8478168 | 0.77 | MAPT (0.55) | SMN1; SMN2MAPTGFERUSP30ITGB3 | |
| SCHEMBL7444560 | 0.76 | ADRB2 (0.66) | SMN1; SMN2TRPV1ADRB2NCF1PLD1 | |
| SCHEMBL9023851 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2TRPV1MAPTGFERCYP46A1 | |
| SCHEMBL9023914 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2TRPV1MAPTGFERCYP46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718287-A2 | Piperazine derivatives, medicaments containing them, their use, and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1996-06-26 | — | — | EP | disclosed |