Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | HMGCR | P04035 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433745 | 0.76 | LMNA (0.59) | LMNAPTGS2MAPTKDM4EPTGDR | |
| SCHEMBL9024624 | 0.74 | PTGS2 (0.50) | LMNAPTGS2MAPTKDM4EPTGDR | |
| SCHEMBL9024081 | 0.73 | LMNA (0.41) | LMNAPTGS2MAPTKDM4EKMT2A | |
| 2,4-Dichlorophenoxyacetic Acid, Methyl Ester SCHEMBL5004223 | 0.72 | MAPT (0.70) | LMNAMAPTPTGDRPTGDR2KMT2A | |
| SCHEMBL1096835 | 0.71 | LMNA (0.60) | LMNAMAPTKDM4EPTGDRPTGDR2 | |
| SCHEMBL6592805 | 0.71 | LMNA (0.60) | LMNAMAPTKDM4EPTGDRPTGDR2 | |
| SCHEMBL221909 | 0.70 | ALDH1A1 (0.32) | MAPTALDH1A1GAA | |
| SCHEMBL2117921 | 0.70 | LMNA (0.59) | LMNAMAPTPTGDRPTGDR2KMT2A | |
| 2,4,5-Trichlorophenoxyacetic Acid, Methyl Ester SCHEMBL29561046 | 0.69 | LMNA (1.00) | LMNAMAPTKDM4EPTGDRPTGDR2 | |
| SCHEMBL13116437 | 0.68 | LMNA (0.57) | LMNAPTGS2MAPTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398179-B1 | Rhodanine derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO (JP) | 1996-01-17 | — | — | EP | disclosed |
| US-5116855-A | Aldose reductase inhibitors; antidiabetic agents | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| EP-0398179-A1 | Rhodanine derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-11-22 | — | — | EP | disclosed |