Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.66 |
| ▸ | DRD2 | P14416 | 6/20 | 0.64 |
| ▸ | DRD3 | P35462 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760177 | 0.83 | HTR1A (0.73) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9024439 | 0.81 | KMT2A (0.64) | HTR1AADRA1AADRA1DADRA1BMAPT | |
| SCHEMBL11676714 | 0.79 | HTR1A (0.64) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| Urapidil SCHEMBL48992 | 0.78 | HTR1A (1.00) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| Urapidil SCHEMBL29363219 | 0.78 | HTR1A (1.00) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL14761169 | 0.78 | ADRA1A (0.71) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL8577935 | 0.78 | DRD2 (0.72) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL11679210 | 0.78 | LMNA (0.66) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL6526368 | 0.77 | DRD2 (0.85) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| Urapidil SCHEMBL1321654 | 0.77 | MAPT (1.00) | HTR1AADRA1AADRA1DADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497659-A1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-08-05 | — | — | EP | claimed |
| EP-0497659-B1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | ESTEVE LABOR DR (ES) | 1996-04-10 | — | — | EP | disclosed |
| US-5382586-A | Tranquilizers | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 1995-01-17 | — | — | US | disclosed |
| US-5292739-A | Aryl(or heteroaryl) piperazinylalkylazole derivatives, their preparation and their application as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1994-03-08 | — | — | US | disclosed |
| EP-0497659-A1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-08-05 | — | — | EP | disclosed |