Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 10/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | POLR1A | O95602 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024060 | 0.80 | KDM4E (0.51) | ALDH1A1HPGDPARP1POLR1AKDM4E | |
| SCHEMBL9023887 | 0.75 | GLA (0.47) | ALDH1A1HPGDKDM4E | |
| SCHEMBL9738372 | 0.70 | NQO2 (0.46) | ALDH1A1HPGDPARP1KDM4EKAT2B | |
| SCHEMBL9025070 | 0.68 | ALDH1A1 (0.43) | ALDH1A1HPGDKDM4ERXFP1 | |
| SCHEMBL9025371 | 0.68 | CYP1A2 (0.44) | ALDH1A1ELANEHPGDPARP1KDM4E | |
| SCHEMBL11380003 | 0.67 | HTR1B (0.52) | ALDH1A1HPGDKDM4EKAT2B | |
| SCHEMBL9024487 | 0.66 | ABCB1 (0.42) | ALDH1A1KDM4E | |
| SCHEMBL9025088 | 0.65 | ALDH1A1 (0.40) | ALDH1A1HPGDPARP1KDM4E | |
| SCHEMBL9024823 | 0.65 | P2RX4 (0.36) | ALDH1A1HPGDPARP1KDM4E | |
| SCHEMBL28245601 | 0.64 | ALDH1A1 (0.63) | ALDH1A1POLR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |