Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023952 | 0.93 | HTR7 (0.41) | HTR7PTGS1CYP19A1RORCNPC1 | |
| SCHEMBL9687914 | 0.83 | HTR7 (0.42) | HTR7PTGS1RORCNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL9024965 | 0.82 | HTR7 (0.41) | HTR7PTGS1RORCNPC1RAB9A | |
| SCHEMBL9024282 | 0.77 | HTR7 (0.42) | HTR7DRD2HTR2AHTR2C | |
| SCHEMBL9024561 | 0.77 | HTR1A (0.45) | HTR7DRD2HTR2AHTR2C | |
| SCHEMBL9024797 | 0.77 | HTR7 (0.36) | HTR7PTGS1CYP19A1DRD2HTR2A | |
| SCHEMBL9689733 | 0.77 | CYP3A4 (0.52) | HTR7NPC1RAB9A | |
| SCHEMBL9024010 | 0.77 | KCNH2 (0.44) | HTR7DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL9024250 | 0.76 | KCNH2 (0.43) | HTR7DRD2HTR2A | |
| SCHEMBL9024850 | 0.76 | HTR2C (0.64) | HTR7DRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474012-B1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5256672-A | Antipsychotic, analgesic | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-10-26 | — | — | US | disclosed |
| US-5180834-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-19 | — | — | US | disclosed |
| US-5114936-A | Antipsychotic and analgesic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0474012-A1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-03-11 | — | — | EP | disclosed |