Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.76 |
| ▸ | CTSS | P25774 | 1/20 | 0.76 |
| ▸ | CTSK | P43235 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | TACR1 | P25103 | 2/20 | 0.67 |
| ▸ | ACE | P12821 | 1/20 | 0.63 |
| ▸ | CCKBR | P32239 | 5/20 | 0.61 |
| ▸ | REN | P00797 | 1/20 | 0.61 |
| ▸ | CCKAR | P32238 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14300166 | 0.91 | CTSL (0.76) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL8233750 | 0.90 | CTSL (0.74) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL23656831 | 0.90 | CTSL (0.74) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL17807348 | 0.89 | CTSL (0.80) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL27871524 | 0.89 | CTSL (0.76) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL27902245 | 0.89 | CTSL (0.76) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL30976323 | 0.89 | ACE (0.77) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL850438 | 0.89 | ACE (0.77) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL1486167 | 0.89 | ACE (0.77) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL29367687 | 0.89 | ACE (0.77) | CTSLCTSSCTSKMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |