Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 2/20 | 0.36 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025568 | 0.88 | METAP2 (0.39) | SLC6A2SLC6A4MAPTMEN1KMT2A | |
| SCHEMBL9032014 | 0.86 | MAPT (0.36) | SLC6A4SCN4AMAPTMEN1KMT2A | |
| SCHEMBL9025431 | 0.79 | MEN1 (0.39) | GAATP53TSHRHPGDMAPT | |
| SCHEMBL9025465 | 0.78 | CCR2 (0.34) | HPGDALDH1A1 | |
| SCHEMBL9026023 | 0.76 | SLC6A4 (0.42) | HTR2CHTR2BHTR2AGAATP53 | |
| SCHEMBL9037251 | 0.75 | CD274 (0.33) | TSHRHPGDMAPT | |
| SCHEMBL9025682 | 0.75 | HTR2C (0.36) | HTR2CTSHRDHFRMAPTMEN1 | |
| SCHEMBL9025089 | 0.74 | KDM4E (0.41) | TP53HPGDMAPTMEN1KMT2A | |
| SCHEMBL9026859 | 0.74 | ADRA2A (0.45) | TSHRHPGDMAPTMEN1KMT2A | |
| SCHEMBL9025520 | 0.74 | METAP2 (0.38) | GAATSHRHPGDMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |