Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | MYB | P10242 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026859 | 0.87 | ADRA2A (0.45) | MEN1POLBKMT2ANQO1ALDH1A1 | |
| SCHEMBL9025089 | 0.87 | KDM4E (0.41) | MEN1KMT2ANQO1ALDH1A1MAPT | |
| SCHEMBL9216019 | 0.86 | NQO1 (0.36) | NQO1MAPTACHEGPR84MYB | |
| SCHEMBL9025568 | 0.86 | METAP2 (0.39) | METAP2MEN1POLBKMT2ANQO1 | |
| SCHEMBL9024896 | 0.86 | MYB (0.36) | MEN1POLBKMT2ANQO1MAPT | |
| SCHEMBL9026008 | 0.86 | PKM (0.38) | NQO1MAPTACHEGPR84 | |
| SCHEMBL9026464 | 0.83 | LTA4H (0.39) | MEN1KMT2ANQO1ALDH1A1MAPT | |
| SCHEMBL9026660 | 0.81 | MAPT (0.35) | MEN1POLBKMT2ANQO1ALDH1A1 | |
| SCHEMBL9032018 | 0.81 | DHFR (0.39) | ALDH1A1MAPTLMNAGAAKDM4E | |
| SCHEMBL9025436 | 0.80 | TSHR (0.39) | MEN1POLBKMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |