Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | MAP2 | P11137 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025568 | 0.88 | METAP2 (0.39) | MAPTMEN1NPC1POLBKMT2A | |
| SCHEMBL9026040 | 0.86 | HTR2C (0.39) | MAPTSLC9A1MEN1POLBKMT2A | |
| SCHEMBL9025431 | 0.79 | MEN1 (0.39) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL9025465 | 0.78 | CCR2 (0.34) | NPC1 | |
| SCHEMBL9031998 | 0.76 | MAPT (0.39) | MAPTCYP1A2CYP2C9CYP2C19SLC9A1 | |
| SCHEMBL9025682 | 0.75 | HTR2C (0.36) | MAPTSLC9A1MEN1NPC1POLB | |
| SCHEMBL9026859 | 0.74 | ADRA2A (0.45) | MAPTCYP1A2MEN1NPC1POLB | |
| SCHEMBL9025520 | 0.74 | METAP2 (0.38) | MAPTMEN1POLBKMT2AMETAP2 | |
| SCHEMBL9025089 | 0.74 | KDM4E (0.41) | MAPTMEN1NPC1KMT2A | |
| SCHEMBL9026660 | 0.74 | MAPT (0.35) | MAPTMEN1POLBKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |