Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.30 |
| ▸ | HTR3B | O95264 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.30 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025988 | 0.84 | HTT (0.35) | HTTSLC9A1 | |
| SCHEMBL9026968 | 0.82 | HTT (0.38) | HTTALDH1A1RAB9ATDP1MAPT | |
| SCHEMBL9026841 | 0.81 | SHMT2 (0.37) | HTTSLC9A1ALDH1A1HTR3EHTR3B | |
| SCHEMBL9025545 | 0.81 | KMT2A (0.34) | HTTSLC9A1ALDH1A1HTR3EHTR3B | |
| SCHEMBL9026477 | 0.80 | SLC9A1 (0.36) | HTTSLC9A1ALDH1A1HTR3EHTR3B | |
| SCHEMBL9026856 | 0.77 | SHMT2 (0.35) | HTTSLC9A1HTR3EHTR3BHTR3A | |
| SCHEMBL9026575 | 0.76 | MAPK1 (0.35) | HTTSLC9A1ALDH1A1MAPT | |
| SCHEMBL9025294 | 0.76 | HTT (0.33) | HTTSLC9A1HTR3EHTR3BHTR3A | |
| SCHEMBL9026534 | 0.76 | SLC9A1 (0.35) | SLC9A1MAPT | |
| SCHEMBL9218813 | 0.76 | HTR3E (0.35) | HTTSLC9A1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |