Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28173861 | 0.93 | TDP1 (0.54) | TDP1MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL1568658 | 0.90 | L3MBTL1 (0.61) | TDP1MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL2546392 | 0.90 | L3MBTL1 (0.61) | TDP1MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL9049960 | 0.84 | MAPT (0.64) | TDP1MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL11094302 | 0.80 | ALDH1A1 (0.59) | TDP1MAPTKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL4654049 | 0.80 | TDP1 (0.72) | TDP1MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL1641651 | 0.78 | KMT2A (0.55) | TDP1MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL28896841 | 0.76 | TDP1 (1.00) | TDP1MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL1837393 | 0.76 | KMT2A (0.53) | TDP1MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL7716853 | 0.76 | L3MBTL1 (0.53) | TDP1MAPTKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660469-B1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO 'B, F! '1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | HELM AG (DE) | 2007-08-29 | — | — | EP | claimed |
| EP-1660469-A1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO 'B, F! '1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | Helm AG (DE) | 2006-05-31 | — | — | EP | claimed |
| WO-2005012274-A1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO `B, F! `1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | HELM AG (DE) | 2005-02-10 | — | — | WO | claimed |
| CN-105859653-B | A kind of synthetic method of Quetiapine | 嘉兴学院 | 2018-12-14 | — | — | CN | disclosed |
| CN-107223121-A | Wet stable holographic media | 科思创德国股份有限公司 | 2017-09-29 | — | — | CN | disclosed |
| CN-105859653-A | Quetiapine synthesizing method | 嘉兴学院 | 2016-08-17 | — | — | CN | disclosed |
| CN-103788014-B | The method of preparation 10H-dibenzo [b, f] [Isosorbide-5-Nitrae] sulphur azatropylidene-11-ketone and Quetiapine | ANHUI ANTENG PHARMACEUTICAL CO., LTD. (CN) | 2016-04-27 | — | — | CN | disclosed |
| WO-2011121602-A1 | PROCESS FOR PREPARATION OF DIBENZOTHIAZEPINONE COMPOUNDS | HIKAL LIMITED (IN) | 2011-10-06 | — | — | WO | disclosed |
| WO-2011121602-A1 | PROCESS FOR PREPARATION OF DIBENZOTHIAZEPINONE COMPOUNDS | HIKAL LIMITED (IN) | 2011-10-06 | — | — | WO | disclosed |
| EP-1781646-B1 | PROCESS FOR THE PREPARATION OF 11-(4-[2-(2-HYDROXYETHOXY)ETHYL]-1-PIPERAZINYL)DIBENZO[b,f][1,4]THIAZEPINE | SK HOLDINGS CO LTD (KR) | 2010-08-18 | — | — | EP | disclosed |
| US-7678902-B2 | Process for the preparation of 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)dibenzo[b,f][1,4]thiazepine | SK HOLDINGS CO., LTD. (KR) | 2010-03-16 | — | — | US | disclosed |
| WO-2006001619-A1 | PROCESS FOR THE PREPARATION OF 11-(4-[2-(2-HYDROXYETHOXY)ETHYL]-I-PIPERAZINYL)DIB ENZO[b,f][l,4]THIAZEPINE | SK CORPORATION (KR) | 2006-01-05 | — | — | WO | disclosed |
| WO-2005012274-A1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO `B, F! `1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | HELM AG (DE) | 2005-02-10 | — | — | WO | disclosed |
| WO-2005012274-A1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO `B, F! `1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | HELM AG (DE) | 2005-02-10 | — | — | WO | disclosed |
| EP-1201663-A1 | PROCESS FOR PRODUCING DIBENZOTHIAZEPINE DERIVATIVES | Ube Industries, Ltd. (JP) | 2002-05-02 | — | — | EP | disclosed |
| EP-0282236-B1 | PROCESS FOR THE PREPARATION OF A THIAZEPINE COMPOUND | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-11 | — | — | EP | disclosed |
| EP-0240228-B1 | THIAZEPINE COMPOUNDS | ICI AMERICAS INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| US-4879288-A | Novel dibenzothiazepine antipsychotic | ICI AMERICAS INC. (US) | 1989-11-07 | — | — | US | disclosed |
| EP-0282236-A1 | Process for the preparation of a thiazepine compound | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-09-14 | — | — | EP | disclosed |
| EP-0240228-A1 | Thiazepine compounds | ICI AMERICAS INC. (US) | 1987-10-07 | — | — | EP | disclosed |