Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9571445 | 0.88 | GABRA1 (0.40) | GABRA1GABRB2CA2GAA | |
| SCHEMBL9028185 | 0.79 | PRKCI (0.36) | GABRA1GABRB2GAAKDM4EGLA | |
| SCHEMBL9028182 | 0.78 | GABRA1 (0.33) | GABRA1GABRB2CA2GAAKDM4E | |
| SCHEMBL9028520 | 0.77 | GAA (0.33) | GABRA1GABRB2GAAKDM4EGLA | |
| SCHEMBL11495679 | 0.76 | GABRA1 (0.42) | GABRA1GABRB2CA2GAAKDM4E | |
| SCHEMBL10413004 | 0.70 | GABRA1 (0.43) | GABRA1GABRB2CA2GAA | |
| SCHEMBL9754486 | 0.70 | GABRA1 (0.43) | GABRA1GABRB2CA2GAAKDM4E | |
| SCHEMBL9026754 | 0.70 | GABRA1 (0.40) | GABRA1GABRB2GAAKDM4EGLA | |
| SCHEMBL9540483 | 0.70 | CA2 (0.45) | GABRA1GABRB2CA2GAAKDM4E | |
| SCHEMBL9201480 | 0.69 | GABRA1 (0.44) | GABRA1GABRB2CA2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5266707-A | Anticholesterol | FUJIREBIO INC. (JP) | 1993-11-30 | — | — | US | disclosed |
| EP-0539709-A1 | 3,5-Dihydroxyheptanoic acid derivatives and lactones thereof as HMG-CoA reductase inhibitors | FUJIREBIO Inc. (JP) | 1993-05-05 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |