Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027573 | 0.74 | KDM4E (0.34) | KDM4EGAATSHRPTGS1ALDH1A1 | |
| SCHEMBL9028266 | 0.74 | KDM4E (0.36) | KDM4ESMN1; SMN2GAATSHRPTGS1 | |
| SCHEMBL9028192 | 0.72 | KDM4E (0.37) | KDM4EPTGS1KMT2A | |
| SCHEMBL9028412 | 0.71 | ADRB2 (0.41) | CYP1A2ADRA2ACYP2D6ADRA2BADRA2C | |
| SCHEMBL11705934 | 0.70 | CYP1A2 (0.39) | CYP1A2ADRA2ACYP2D6PKMADRA2B | |
| SCHEMBL9028770 | 0.69 | RXRA (0.35) | CYP1A2ADRA2ACYP2D6PKMADRA2B | |
| SCHEMBL9028742 | 0.66 | THRB (0.40) | CYP1A2ADRA2ACYP2D6PKMADRA2B | |
| SCHEMBL9028771 | 0.66 | KDM4E (0.36) | CYP1A2CYP2D6ADRA1AKDM4EGAA | |
| SCHEMBL8600805 | 0.66 | HTT (0.44) | CYP1A2ADRA2ACYP2D6PKMADRA2B | |
| SCHEMBL9027557 | 0.64 | ACHE (0.40) | CYP1A2CYP2D6ADRA1AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |