Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.60 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | MAP3K12 | Q12852 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902272 | 0.89 | SYK (0.53) | SYKKARS1MAP3K12 | |
| SCHEMBL901953 | 0.88 | KARS1 (0.56) | SYKKARS1MAP3K12 | |
| SCHEMBL1705310 | 0.86 | KARS1 (0.48) | SYKKARS1JAK2JAK3PTK2 | |
| SCHEMBL902237 | 0.85 | KARS1 (0.67) | SYKKARS1JAK2JAK3 | |
| SCHEMBL1704909 | 0.84 | KARS1 (0.67) | SYKKARS1 | |
| SCHEMBL1705277 | 0.81 | JAK2 (0.44) | SYKJAK2JAK3PTK2 | |
| SCHEMBL16220351 | 0.79 | SYK (0.62) | SYKMAP3K12 | |
| SCHEMBL901925 | 0.79 | KARS1 (0.67) | SYKKARS1MAP3K12 | |
| SCHEMBL901734 | 0.77 | HTT (0.46) | JAK2JAK3PTK2 | |
| SCHEMBL901929 | 0.77 | KARS1 (0.55) | SYKKARS1MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |