Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.44 |
| ▸ | JAK3 | P52333 | 8/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.40 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902272 | 0.85 | SYK (0.53) | SYKWNT3A | |
| SCHEMBL902875 | 0.85 | IGF1R (0.42) | JAK2JAK3PTK2IGF1RNAMPT | |
| SCHEMBL1704583 | 0.84 | ADORA2A (0.48) | JAK2JAK3PTK2ALDH1A1GPR119 | |
| SCHEMBL1705310 | 0.83 | KARS1 (0.48) | JAK2JAK3PTK2IGF1RSYK | |
| SCHEMBL902839 | 0.81 | SYK (0.60) | JAK2JAK3PTK2SYK | |
| SCHEMBL1704989 | 0.81 | NAMPT (0.44) | NAMPT | |
| SCHEMBL901734 | 0.79 | HTT (0.46) | JAK2JAK3PTK2NAMPTHPGD | |
| SCHEMBL29386809 | 0.74 | GPR119 (0.55) | NAMPTKDM4EGPR119 | |
| SCHEMBL12354143 | 0.74 | GPR119 (0.55) | NAMPTKDM4EGPR119 | |
| SCHEMBL1704829 | 0.73 | KARS1 (0.43) | JAK2JAK3HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |