Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.67 |
| ▸ | SYK | P43405 | 10/20 | 0.58 |
| ▸ | PHGDH | O43175 | 4/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704909 | 0.90 | KARS1 (0.67) | KARS1SYK | |
| SCHEMBL901891 | 0.88 | KARS1 (0.73) | KARS1SYKPHGDHRAB9ACACNA1B | |
| SCHEMBL902983 | 0.85 | KARS1 (0.64) | KARS1SYKADORA2APDE4DJAK2 | |
| SCHEMBL902839 | 0.85 | SYK (0.60) | KARS1SYKJAK2JAK3 | |
| SCHEMBL1704583 | 0.80 | ADORA2A (0.48) | KARS1ADORA2APDE4DJAK2JAK3 | |
| SCHEMBL901727 | 0.80 | KARS1 (1.00) | KARS1SYKPHGDH | |
| SCHEMBL901697 | 0.79 | KARS1 (0.65) | KARS1SYK | |
| SCHEMBL20516341 | 0.78 | ADORA2A (0.53) | ADORA2APDE4DJAK2JAK3 | |
| SCHEMBL30791110 | 0.78 | ADORA2A (0.53) | ADORA2APDE4DJAK2JAK3 | |
| SCHEMBL1704409 | 0.77 | KARS1 (0.73) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |