Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901682 | 0.83 | ASIC3 (0.44) | — | |
| SCHEMBL5352510 | 0.82 | TRPV3 (0.51) | HTTNAMPTGPR119KDM4EMAPT | |
| SCHEMBL12354143 | 0.82 | GPR119 (0.55) | NAMPTGPR119KDM4EMAPTHPGDS | |
| SCHEMBL29386809 | 0.82 | GPR119 (0.55) | NAMPTGPR119KDM4EMAPTHPGDS | |
| SCHEMBL30376009 | 0.81 | GPR119 (0.54) | NAMPTGPR119KDM4EMAPTTHRB | |
| SCHEMBL835855 | 0.81 | GPR119 (0.54) | NAMPTGPR119KDM4EMAPTTHRB | |
| SCHEMBL902759 | 0.81 | ADORA2A (0.60) | JAK2JAK3GPR119MAPTALDH1A1 | |
| SCHEMBL1705277 | 0.79 | JAK2 (0.44) | HTTNAMPTJAK2JAK3PTK2 | |
| SCHEMBL902272 | 0.79 | SYK (0.53) | — | |
| SCHEMBL1705310 | 0.79 | KARS1 (0.48) | JAK2JAK3PTK2GPR119HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |