Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LIG1 | P18858 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28640918 | 0.78 | ALDH1A1 (0.51) | ALDH1A1NPC1RAB9AHPGDTSHR | |
| SCHEMBL9251894 | 0.78 | ALDH1A1 (0.54) | ALDH1A1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL28032566 | 0.77 | ALDH1A1 (0.45) | LTB4RLTB4R2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9028412 | 0.77 | ADRB2 (0.41) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL9027262 | 0.73 | IAPP (0.38) | HTR1A | |
| SCHEMBL9027559 | 0.73 | LTA4H (0.40) | ALDH1A1KDM4EMAPTLMNACYP2D6 | |
| SCHEMBL9028266 | 0.72 | KDM4E (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL9026754 | 0.69 | GABRA1 (0.40) | ALDH1A1TSHRMAPK1HSD17B10KDM4E | |
| SCHEMBL27909063 | 0.68 | MAPT (0.43) | ALDH1A1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL2844525 | 0.68 | HPGD (0.43) | ALDH1A1HPGDTSHRMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |