Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704829 | 0.89 | KARS1 (0.43) | ADORA2AJAK2JAK3KARS1ALDH1A1 | |
| SCHEMBL1705277 | 0.84 | JAK2 (0.44) | JAK2JAK3GPR119PTK2ALDH1A1 | |
| SCHEMBL902983 | 0.82 | KARS1 (0.64) | ADORA2AJAK2JAK3GPR119PTK2 | |
| SCHEMBL1704989 | 0.82 | NAMPT (0.44) | — | |
| SCHEMBL902237 | 0.80 | KARS1 (0.67) | ADORA2AJAK2JAK3KARS1PDE4D | |
| SCHEMBL902759 | 0.78 | ADORA2A (0.60) | ADORA2AJAK2JAK3GPR119KIT | |
| SCHEMBL20516341 | 0.74 | ADORA2A (0.53) | ADORA2AJAK2JAK3GPR119KIT | |
| SCHEMBL30791110 | 0.74 | ADORA2A (0.53) | ADORA2AJAK2JAK3GPR119KIT | |
| SCHEMBL901697 | 0.74 | KARS1 (0.65) | KARS1CKS1BSKP1SKP2 | |
| SCHEMBL1704903 | 0.73 | GRM1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |