Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033881 | 0.93 | ALDH1A1 (0.43) | HTTATMSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL9033512 | 0.86 | POLB (0.46) | HTTKMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL9033473 | 0.81 | ANPEP (0.47) | SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL9033517 | 0.79 | POLB (0.40) | HTTKMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL9033478 | 0.77 | ANPEP (0.44) | SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL9032637 | 0.77 | MEN1 (0.46) | SMN1; SMN2ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL9033533 | 0.77 | HPGD (0.31) | HTT | |
| SCHEMBL9032679 | 0.75 | L3MBTL1 (0.31) | L3MBTL1 | |
| SCHEMBL9033796 | 0.73 | KCNH2 (0.41) | ALDH1A1 | |
| SCHEMBL9033537 | 0.72 | L3MBTL1 (0.32) | HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696593-A2 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-02-14 | — | — | EP | disclosed |