Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LONP1 | P36776 | 16/20 | 0.79 |
| ▸ | PSMB5 | P28074 | 9/20 | 0.51 |
| ▸ | PSMB11 | A5LHX3 | 7/20 | 0.51 |
| ▸ | PSMA7 | O14818 | 7/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 7/20 | 0.51 |
| ▸ | PSMA1 | P25786 | 7/20 | 0.51 |
| ▸ | PSMA2 | P25787 | 7/20 | 0.51 |
| ▸ | PSMA3 | P25788 | 7/20 | 0.51 |
| ▸ | PSMA4 | P25789 | 7/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 7/20 | 0.51 |
| ▸ | PSMB9 | P28065 | 7/20 | 0.51 |
| ▸ | PSMA5 | P28066 | 7/20 | 0.51 |
| ▸ | PSMB4 | P28070 | 7/20 | 0.51 |
| ▸ | PSMB6 | P28072 | 7/20 | 0.51 |
| ▸ | PSMB10 | P40306 | 7/20 | 0.51 |
| ▸ | PSMB3 | P49720 | 7/20 | 0.51 |
| ▸ | PSMB2 | P49721 | 7/20 | 0.51 |
| ▸ | PSMA6 | P60900 | 7/20 | 0.51 |
| ▸ | PSMA8 | Q8TAA3 | 7/20 | 0.51 |
| ▸ | PSMB7 | Q99436 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL464440 | 0.88 | LONP1 (1.00) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL464441 | 0.84 | LONP1 (0.69) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL11921052 | 0.83 | LONP1 (0.59) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL464415 | 0.83 | LONP1 (0.68) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL464464 | 0.81 | LONP1 (0.64) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL21558303 | 0.79 | LONP1 (0.62) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL15161123 | 0.77 | LONP1 (0.60) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL3653585 | 0.73 | KDM4E (0.58) | LONP1KDM4E | |
| SCHEMBL20365811 | 0.72 | LONP1 (0.70) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL464431 | 0.72 | LONP1 (0.70) | LONP1PSMB5PSMB11PSMA7PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200323889-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CERULEAN PHARMA INC. | 2020-10-15 | — | — | US | disclosed |
| US-20180193486-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND OTHER DISEASE | CERULEAN PHARMA INC. | 2018-07-12 | — | — | US | disclosed |
| US-20180110791-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CERULEAN PHARMA INC. | 2018-04-26 | — | — | US | disclosed |
| US-20160058874-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CERULEAN PHARMA INC. (US) | 2016-03-03 | — | — | US | disclosed |
| US-20150005230-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CERULEAN PHARMA INC. (US) | 2015-01-01 | — | — | US | disclosed |
| US-20140378414-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CERULEAN PHARMA INC (US) | 2014-12-25 | — | — | US | disclosed |
| US-20140328918-A1 | METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS | CERULEAN PHARMA INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140255374-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND OTHER DISEASE | CERULEAN PHARMA INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20130196906-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CERULEAN PHARMA INC. (US) | 2013-08-01 | — | — | US | disclosed |
| WO-2013025490-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND OTHER DISEASES | CERULEAN PHARMA INC. (US) | 2013-02-21 | — | — | WO | disclosed |
| EP-2212334-B1 | PROTEASOME INHIBITORS | MILLENNIUM PHARM INC (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2012044832-A1 | METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS | FETZER OLIVER S (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2011090940-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CERULEAN PHARMA INC. (US) | 2011-07-28 | — | — | WO | disclosed |
| US-7838673-B2 | Proteasome inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-11-23 | — | — | US | disclosed |
| US-7838673-B2 | Proteasome inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-11-23 | — | — | US | disclosed |
| US-7838673-B2 | Proteasome inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-11-23 | — | — | US | disclosed |
| US-20090099132-A1 | Proteasome inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-20090099132-A1 | Proteasome inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-20090099132-A1 | Proteasome inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180110791-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | PSMG3, COPB1, PSMA6 | LONP1 1116/4885PSMB5 18/4885PSMB11 5/4885 |
| US-20180193486-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND OTHER DISEASE | PHOSPHO1, SGMS1, SGMS2 | LONP1 4183/4885PSMB5 1149/4885PSMB11 1339/4885 |
| US-20130196906-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CDR2, DDOST, GALC | LONP1 3967/4885PSMB5 1902/4885PSMB11 1829/4885 |
| US-20140255374-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND OTHER DISEASE | PHOSPHO1, SGMS1, SGMS2 | LONP1 4183/4885PSMB5 1149/4885PSMB11 1339/4885 |
| US-20140328918-A1 | METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS | HLA-DRB1, TSG101, IAPP | LONP1 3292/4885PSMB5 650/4885PSMB11 578/4885 |
| US-20090099132-A1 | Proteasome inhibitors | PSMB5, PSMG3, PSMB1 | LONP1 341/4885PSMB5 1/4885PSMB11 4/4885 |
| US-20200323889-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | PSMG3, COPB1, PSMA6 | LONP1 1116/4885PSMB5 18/4885PSMB11 5/4885 |
| US-20150005230-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CDR2, DDOST, GALC | LONP1 3967/4885PSMB5 1902/4885PSMB11 1829/4885 |
| US-20160058874-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | CDR2, DDOST, GALC | LONP1 3967/4885PSMB5 1902/4885PSMB11 1829/4885 |
| US-20140378414-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY | PSMG3, COPB1, PSMA6 | LONP1 1116/4885PSMB5 18/4885PSMB11 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.