Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28102426 | 0.83 | MRGPRX4 (0.67) | MRGPRX4HTR6FFAR1FFAR4CCR5 | |
| SCHEMBL182637 | 0.80 | HTR1A (0.53) | MRGPRX4MAOBNPC1RAB9A | |
| SCHEMBL18707175 | 0.78 | RAB9A (0.45) | CCR5MAOBNPC1RAB9A | |
| SCHEMBL20076960 | 0.77 | MRGPRX4 (0.60) | MRGPRX4HTR6PLK1SLC6A4MAOB | |
| SCHEMBL863622 | 0.77 | FFAR1 (0.58) | MRGPRX4HTR6FFAR1FFAR4PDCD1 | |
| SCHEMBL9034724 | 0.76 | ALDH1A1 (0.61) | MRGPRX4HTR6PLK1CCR5PDCD1 | |
| SCHEMBL8549374 | 0.76 | FFAR1 (0.60) | MRGPRX4FFAR1FFAR4MAOBNPC1 | |
| SCHEMBL3324129 | 0.76 | MAOB (0.54) | MRGPRX4MAOB | |
| SCHEMBL919374 | 0.75 | FFAR1 (0.53) | MRGPRX4FFAR1FFAR4PDCD1CD274 | |
| SCHEMBL339374 | 0.74 | HTR1A (0.53) | MRGPRX4MAOBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365328-B1 | Pyridine derivatives | ZENECA LTD (GB) | 1996-04-03 | — | — | EP | disclosed |
| US-5053415-A | Antiischemic, antiinflammatory, antiarthritic agents, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-10-01 | — | — | US | disclosed |
| EP-0365328-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1990-04-25 | — | — | EP | disclosed |