Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | PTPRC | P08575 | 4/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | PTPRF | P10586 | 1/20 | 0.47 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9042143 | 0.88 | MRGPRX4 (0.55) | MRGPRX4PTPRCPTPN1PTPN2PTPRF | |
| SCHEMBL9042414 | 0.81 | LTA4H (0.57) | PTPRCPTPN1PTPN2PTPRFLTA4H | |
| SCHEMBL9043489 | 0.79 | CYP1A2 (0.55) | PTPRCPTPN1PTPN2PTPRFFFAR1 | |
| SCHEMBL9041398 | 0.75 | MRGPRX4 (0.49) | MRGPRX4NAMPTKMT2APPARG | |
| SCHEMBL1123048 | 0.74 | PKM (0.61) | MRGPRX4FFAR1PPARG | |
| SCHEMBL9040124 | 0.73 | FFAR1 (0.64) | PTPRCPTPN1PTPN2PTPRFFFAR1 | |
| SCHEMBL9042801 | 0.73 | PTPRC (0.53) | PTPRCPTPN1PTPN2PTPRFLTA4H | |
| SCHEMBL367918 | 0.73 | MRGPRX4 (0.76) | MRGPRX4CYP4F2CYP4A11 | |
| SCHEMBL9042676 | 0.72 | TBXAS1 (0.55) | PTPRCPTPN1PTPN2FFAR1KMT2A | |
| SCHEMBL9040525 | 0.71 | PTPN1 (0.73) | MRGPRX4PTPRCPTPN1PTPN2PTPRF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512352-B1 | Substituted carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | claimed |
| EP-0512352-B1 | Substituted carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | disclosed |
| US-5344843-A | Carnitine acryltransferase enzyme inhibitors as antiischemic agents and for cardiovascular disorders | HOFFMAN-LA ROCHE INC. (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0512352-A2 | Substituted carboxylic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-11 | — | — | EP | disclosed |