Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 0.57 |
| ▸ | GART | P22102 | 4/20 | 0.54 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.50 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.50 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.50 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.50 |
| ▸ | ATIC | P31939 | 2/20 | 0.49 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.49 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9042931 | 0.86 | DHFR (0.60) | DHFRGARTFOLR2FOLR1SLC46A1 | |
| SCHEMBL9041817 | 0.85 | MTHFD1 (0.59) | DHFRGARTATIC | |
| SCHEMBL8997257 | 0.85 | GART (0.61) | DHFRGARTATIC | |
| SCHEMBL9041263 | 0.85 | DHFR (0.50) | DHFRGART | |
| SCHEMBL9041254 | 0.85 | DHFR (0.50) | DHFRGART | |
| SCHEMBL8565751 | 0.85 | DHFR (0.57) | DHFRGARTFOLR2FOLR1SLC19A1 | |
| SCHEMBL8997170 | 0.85 | DHFR (0.55) | DHFRGARTATIC | |
| SCHEMBL9758306 | 0.85 | DHFR (0.55) | DHFRGARTATIC | |
| SCHEMBL9088274 | 0.84 | ATIC (0.51) | DHFRGARTATIC | |
| SCHEMBL9227797 | 0.84 | DHFR (0.57) | DHFRGARTFOLR2FOLR1SLC46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0400562-B1 | Pyrrolopyrimidines, their production and use as tumoricidal agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-08-21 | — | — | EP | disclosed |