Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 5/20 | 0.46 |
| ▸ | ATIC | P31939 | 4/20 | 0.45 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | GART | P22102 | 9/20 | 0.44 |
| ▸ | FOLR2 | P14207 | 2/20 | 0.41 |
| ▸ | FOLR1 | P15328 | 2/20 | 0.41 |
| ▸ | SLC46A1 | Q96NT5 | 2/20 | 0.41 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL573199 | 0.94 | DHFR (0.52) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9049515 | 0.90 | CA2 (0.44) | DHFRATICSHMT1SHMT2CA2 | |
| SCHEMBL9047109 | 0.87 | CA2 (0.47) | DHFRATICSHMT1SHMT2CA2 | |
| SCHEMBL9047497 | 0.87 | GART (0.42) | DHFRATICSHMT1SHMT2CA2 | |
| SCHEMBL9044532 | 0.85 | ATIC (0.46) | ATICSHMT1SHMT2GARTFOLR2 | |
| SCHEMBL9048103 | 0.85 | GART (0.44) | DHFRATICSHMT1SHMT2CA2 | |
| SCHEMBL9045940 | 0.83 | ATIC (0.47) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9046824 | 0.82 | ATIC (0.55) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9342476 | 0.82 | ATIC (0.48) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9045385 | 0.81 | FOLR2 (0.51) | DHFRATICSHMT1SHMT2GART |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | claimed |