Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9046002 | 0.89 | MAPK8 (0.47) | RORCMAPK8CYP3A4CYP2C9ATM | |
| SCHEMBL10593432 | 0.84 | GLA (0.35) | HTR1AHTR2AHTR7HTR6L3MBTL1 | |
| Bicarbonate SCHEMBL9044272 | 0.82 | RORC (0.47) | RORCCYP3A4CYP2C9KMT2AMEN1 | |
| SCHEMBL9147090 | 0.81 | EPHA2 (0.53) | RORCCAPN1EPHA2FLT4GSK3B | |
| SCHEMBL9416468 | 0.76 | MAPK8 (0.43) | L3MBTL1CAPN1EPHA2FLT4GSK3B | |
| Bicarbonate SCHEMBL9046548 | 0.74 | PTGS1 (0.43) | RORCMAPK8CYP3A4CYP2C9KMT2A | |
| SCHEMBL500692 | 0.74 | LMNA (0.56) | CAPN1EPHA2FLT4GSK3BRARB | |
| SCHEMBL9044837 | 0.73 | GLA (0.40) | L3MBTL1EPHA2FLT4GSK3BRARB | |
| SCHEMBL2087613 | 0.73 | LMNA (0.53) | RORCEPHA2FLT4GSK3BRARB | |
| SCHEMBL6216178 | 0.73 | LMNA (0.50) | HTR1AHTR2AHTR7HTR6RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422485-B1 | Quinolone carboxylic acid derivatives, process for their preparation and their use | BAYER AG (DE) | 1996-04-03 | — | — | EP | disclosed |
| EP-0422485-A2 | Quinolone carboxylic acid derivatives, process for their preparation and their use | BAYER AG (DE) | 1991-04-17 | — | — | EP | disclosed |